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The idea of the anti-inflammatory properties of vitamin D has been further supported by a clinical study that reported how concentrations of IL-1β, IL-6, interleukin-8, macrophage inflammatory protein 1β, monocyte chemoattractant protein-1, and IFN-inducible protein 10 markedly decreased after co-treatment with vitamins D and B12
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But it will be recognized by the immune system in excess, activating the Toll-like receptor 4 (TLR 4) signaling pathway, and promoting the release of immune cells to release a large number of pro-inflammatory cytokines, such as TNF- α and IL-6 (Qu et al., 2023)
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