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Acceleration of glutathione efflux and inhibition of γ- glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity

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This NRF2 × GCLC interaction means that NFE2L2 genetic variants that reduce NRF2 activity compound GCLC promoter variant effects — reducing both baseline expression and stress-induced GCLC upregulation simultaneously