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The Cochrane concluded that orally administered vitamin B12 appeared to be as effective as the intramuscular route with respect to the short-term haematological and neurological responses observed in patients with deficiencies, but highlighted methodological limitations in both trials
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In conjunction with the mucosal layer and specialized cells, the epithelial layer forms a well-equipped, intricately regulated and stringent barrier with continuous scrutiny by immune cells to create an immune-silent environment
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